cmpA [2018-06-07 18:47:37]

cortex morphogenic protein A, checkpoint protein, orchestrates spore coat and cortex morphogenesis

locus: G8J2-20

pI: 0.00

mw: 4.00 kDa

function: represses cortex assembly until the successful initiation of spore coat assembly

product: cortex morphogenic protein A, adapter protein targeting SpoIVA for degradation by ClpXP upon spore envelope defects

synonyms

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.1|Spore coat proteins] → [category|SW 4.2.1.1.8|Not yet assigned]

Gene

Coordinates: 525,021 → 528,076

Phenotypes of a mutant

• quicker progressing through the [SW|sporulation ] cycle [Pubmed|22463703]
• overexpression of CmpA results in heat-sensitive sporulation [Pubmed|22463703,26387458], this can be suppressed by mutations in ''[gene|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP]'' and ''[gene|297F53DAD3351E0C55108DD2C93B78FFB174438C|clpX]'' [Pubmed|26387458]

Protein

Catalyzed reaction/ biological activity

• orchestrates spore coat and cortex assembly [Pubmed|22463703]
• represses cortex assembly until spore coat assembly successfully initiates [Pubmed|22463703]

[SW|Localization]

• surface of the developing spore, this depends on a functional [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA] [Pubmed|22463703,26387458]

[SW|Interactions]

• [protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|ClpX]-[protein|85DE3CB6CDA61C141C6030367C0A13BB642160B9|CmpA] (for [protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|ClpX]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|ClpP]-dependent degradation of [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA]) [Pubmed|26387458]
• [protein|85DE3CB6CDA61C141C6030367C0A13BB642160B9|CmpA]-[protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA] (for [protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|ClpX]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|ClpP]-dependent degradation of [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA]) [Pubmed|26387458]

Expression and Regulation

Operons

• genes: [gene|85DE3CB6CDA61C141C6030367C0A13BB642160B9|cmpA]
  description: [Pubmed|22463703,20709900]

  sigma factors

  • [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]: sigma factor, [Pubmed|22463703], in [regulon|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE regulon]

  regulatory mechanism

  • [protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID]: activation, [Pubmed|22463703], in [regulon|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID regulon]

  regulation

  • expressed in mother cell during [SW|sporulation ] ([protein|search|SigE], [SW|SpoIIID]) [Pubmed|22463703]

References

Reviews

• 27227299,26418292,28408070

Original publications

• 22463703,26387458,20709900